Noninvasive Neurocybernetic Flow Laboratory

Our mission is  to understand human brain function using  flow
dynamics of blood and cerebrospinal fluid.
Est. 1987

Njemanze PC. Cerebral lateralisation for facial processing: Gender-related cognitive styles
determined using Fourier analysis of mean cerebral blood flow velocity in the middle cerebral arteries.
      Laterality 12(1), 31-49, Jan 2007 [PDF]
Njemanze PC. Cerebral lateralization and general intelligence: Gender differences in a transcranial
Doppler study. Brain and Language, Feb. 2005. [Abstract]
Njemanze PC. Asymmetry of cerebral blood flow velocity response to color processing and hemodynamic
changes during -6 degrees 24-hour head-down bed rest in men. Journal of Gravitational Physiology. 12(2),
33-41. Dec 2005.
Njemanze PC. Asymmetry in cerebral blood flow velocity with processing of facial images during  
head-down rest. Aviation Space and Environmental Medicine. 75(9), 800-805. Sep 2004 [PUBMED]
Njemanze PC. Crossed aphasia in a dextral with right hemispheric lesion: a functional transcranial
Doppler study. Stroke; a Journal of Cerebral Circulation. 34(11), e213-4; Nov 2003. [PUBMED][Full-
text]
Njemanze PC. Differential effect of body adiposity and serum lipids on right and left carotid artery
lesions. Stroke. 34, 185-186. 3 Oct 2003. [PUBMED][Full-text]
Njemanze PC. Cerebral lateralization for motor tasks in simulated microgravity. A transcranial Doppler
technique for astronauts. Journal of Gravitational Physiology. 9(1), 33-34. Jul 2002. [PUBMED]
Njemanze PC, Sunderland A. Carotid stenosis determines impairment of ipsilateral dexterity in stroke.
Stroke; a Journal of Cerebral Circulation. 31(2), 545-6. Feb 2000.  [PUBMED]
Njemanze PC, Chidi-Ebere A. Three-dimensional vector component analysis of neurological stroke
scales. Stroke; a Journal of Cerebral Circulation. 30(8), 1731-3. Aug 1999. [PUBMED][Full-text]
Njemanze PC. Cerebral lateralization in random letter task in the visual modality: a transcranial
Doppler study. Brain and Language. 53(3), 315-25. Jun 1996.  [PUBMED]
Njemanze PC. Cerebrovascular dysautoregulation syndrome complex - brain hypoperfusion precedes
hypotension and cardiac asystole. Japanese Circulation Journal. 58(4), 293-7. Apr 1994.  [PUBMED]
Njemanze PC, Antol PJ, Lundgren CE. Perfusion of the visual cortex during pressure breathing at
different high-G stress profiles. Aviation, Space, and Environmental Medicine. 64(5), 396-400. May
1993.  [PUBMED]




Njemanze PC. Cerebral circulation dysfunction and hemodynamic abnormalities in syncope during
upright tilt test. The Canadian Journal of Cardiology. 9(3), 238-42. Apr 1993.  [PUBMED]
Njemanze PC. Isoproterenol induced cerebral hypoperfusion in a heart transplant recipient. Pacing
and Clinical Electrophysiology : PACE. 16(3 Pt 1), 491-5. Mar 1993.  [PUBMED]
Njemanze PC. Cerebral circulatory changes in case of pacemaker syndrome. Journal of
Cardiovascular Technology. 11, 105-109. 1993.
Njemanze PC. Critical limits of pressure-flow relation in the human brain. Stroke; a Journal of
Cerebral Circulation. 23(12), 1743-7. Dec 1992. [PUBMED]
Njemanze PC. Handedness and carotid plaque lesion. Stroke; a Journal of Cerebral Circulation. 23
(11), 1679-80. Nov 1992.  [PUBMED]
Gomez CR, McLaughlin JR, Njemanze PC, Nashed A. Effect of cardiac dysfunction upon diastolic
cerebral blood flow. Angiology. 43(8), 625-30. Aug 1992.  [PUBMED]
Njemanze PC, Gomez CR, Horenstein S. Cerebral lateralization and color perception: a transcranial
Doppler study. Cortex; a Journal Devoted to the Study of the Nervous System and Behavior. 28(1),
69-75. Mar 1992. [PUBMED]
Njemanze PC, Mirza WU, Rosenfeld WE, and Njemanze VU.. Cerebral blood flow velocity and EEG
amplitude in generalized seizures: a case study. Journal of Neuroimaging. 2, 151-155. 1992.
Njemanze PC. Cerebrovascular dysautoregulation syndrome in heart-lung transplant recipient.
Journal of Cardiovascular Technology 10: 227-232, 1992.
Njemanze PC. Cerebral lateralization in linguistic and nonlinguistic perception: analysis of cognitive
styles in the auditory modality. Brain and Language. 41(3), 367-80. Oct 1991. [PUBMED]
Njemanze PC. Transcranial Doppler evaluation of syncope: an application in aerospace physiology.
Aviation, Space, and Environmental Medicine. 62(6), 569-72. Jun 1991.  [PUBMED]
Njemanze PC, Beck OJ, Gomez CR, Horenstein S. Fourier analysis of the cerebrovascular system.
Stroke; a Journal of Cerebral Circulation. 22(6), 721-6. Jun 1991.  [PUBMED]








Gomez CR, McLaughlin JR, Njemanze PC. Effect of intra-aortic balloon pumps on cerebral
circulation. Stroke; a Journal of Cerebral Circulation. 21(10), 1512-3. Oct 1990.  [PUBMED]
Njemanze PC, Beck OJ. MR-gated intracranial CSF dynamics: evaluation of CSF pulsatile flow.
AJNR American Journal of Neuroradiology. 10(1), 77-80. 1989.  [PUBMED]




Noninvasive transcranial Doppler ultrasound face and object recognition testing system, Patent
Number: 6773400, 2004, Self-owned, United States of America. [Full-text]
Transcranial Doppler spectroscopy for assessment of brain cognitive functions, Patent Number:
20040158155, 2004, Self-owned, United States of America.   [Full-text]
Intelligent Transcranial Doppler Probe, Patent Number: 6547737, 2003, Self-owned, United States.  
[Full-text]
Transcranial Doppler Ultrasound Device for Odor Evaluation, Patent Number: 6663571, 2003, United
States of America. [Full-text]  
Neural Network System for Modeling Ecological and Biological Systems, Patent Number: 6490573,
2002, Self-owned, United States. [Full-text]  
Noninvasive transcranial Doppler Ultrasound Computerized Mental Performance Testing System,
Patent Number: 6390979, 2002, Self-owned, United States. [Full-text]  
Implantable Telemetric Transcranial Doppler Device, Patent Number: 6468219, 2002, Self-owned,
United States. [Full-text]  
Physiologic G-suit modulator. Patent Number: 5121744, 1992, Self-owned, United States. [Full-text]  
Representative Works

CyberLab - Laboratory of Brain Control Systems
Mission Statement
email: neurocybernetics@chidicon.com
The Neurocybernetic Flow Laboratory or CyberLab was
established in 1987, with international collaboration.  The
goal is to study brain function as it relates to blood flow and
cerebrospinal fluid (CSF). CSF flow dynamics was studied
with the emerging magnetic resonance imaging (MRI)
technology at the time. CSF pulsatile flow in relation to
vascular pulsation was established using phase contrast
MRI [
PUBMED]. Studies of brain control function examined
the relationship of both hemispheres, and the relationship
of brain-to-heart function, as the basis of conscious
experience. Blood flow studies used transcranial Doppler
ultrasound to examine cerebral lateralization of cognitive
function including language in the auditory [
PUBMED] and
visual  modalities [
PUBMED], colors [PUBMED],
intelligence [PDF], faces [
PUBMED] and motor [PUBMED].  
The brain-heart functional relationship studies, used
syncope as a model with the goal to determine the critical
level of pressure-flow relationship for conscious experience [
PUBMED], in persons with intact heart for the different  
types of syncope [
PUBMED], and the relationship in
denervated heart [
PUBMED]. Conversely, operational
failure of  human  consciousness  such as due to
gravitational loss of consciousness (GLOC) calls for
man-machine interface at critical periods. It was therefore  
essential to determine the susceptibility to syncope
[
PUBMED], as well as sensing impending syncope
[
PUBMED]. Spin-offs for  industry [www.chidiconinc.com].
CSF in Systole  &  Diastole  - AJNR 10: 77-80 1989
Baseline
Baseline
Type I syncope
Type II syncope
Type I & Type II  - Can J Cardiol.9: 238-42; 1993
Publications
Publications contd.
Publications contd.
Patents for Licensing